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Methods This retrospective cohort study included data on US adults with T2D receiving SGLT2i from Komodos Healthcare Map from January 1, 2017, to June 30, 2023

Results CNR1 expression was upregulated in circulating CD4+ T cells from individuals at type 1 diabetes onset (6.9-fold higher vs healthy individuals) and in sorted islet beta cells from donors with type 1 diabetes (3.6-fold higher vs healthy counterparts)

In-clinic and virtual visits available.

Notably, no permanent treatment discontinuations or dose reductions due to gastrointestinal side effects were reported in ribupatide-treated participants

Serious Side Effects (Seek Immediate Medical Attention)