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Description
The LEADER trial included only high-risk CV patients, so the demonstrated CV benefit may be significantly diluted among the general T2DM population
Weight Loss Q&A Am I a good candidate for GLP-1 treatment
aleniglipron and orforglipron) are functionally Gs-biased and recruit -arrestin poorly (which is typically involved in turning off the GLP-1 receptor's signal by promoting internalization and downregulation and mediating nausea and vomiting)
The 503b pharmacies are regulated by the FDA, and some of them do contract manufacturing for pharmaceutical companies
Skip it at your own risk
