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Retatrutide has shown the highest weight loss numbers in trials so far (28.7% in Phase 3 TRIUMPH-4 vs 22.5% for tirzepatide in SURMOUNT-1 and 15.8% for semaglutide in STEP-1)

Diabetic nephropathy: An FDA decision for semaglutide (Ozempic) for the prevention of diabetic nephropathy in adults with T2DM and cardiovascular disease (CVD) is expected in January 2025

Adding 150 minutes weekly of moderate activity amplifies weight loss and improves cardiovascular outcomes beyond what medication alone achieves

This reduces the risk of hypoglycaemia compared with some other diabetes medications, although this risk increases when combined with insulin or sulfonylureas

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