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Severe kidney or liver disease
Long-acting basal insulins (for example Lantus, Levemir, Tresiba) have a slow, steady effect to cover background needs
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Tirzepatide works by mimicking the actions of two natural hormonesGLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)that play a vital role in regulating blood sugar and appetite
Early, in-depth review article that evaluates the similarities and differences between short-acting and long-acting GLP-1R agonists in terms of glucose-lowering efficacy and adverse effects, and discusses the possibilities for utilizing these agents for individualized treatment of T2DM
