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Description
Your kidneys filter creatinine from the blood and excrete it in urine
Jumping to the full dose immediately would produce severe nausea and vomiting in most people

[DOI] [PubMed] [Google Scholar] Wettergren A., Wojdemann M., Meisner S., Stadil F., Holst J.J
Or tirzepatide constipation might ease up when switching to semaglutide, which carries its own GI profile

A full list of side effects can be found here