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Patients were randomized in a 1:1:1:1 ratio to once weekly fixed dosage of ZEPBOUND 5 mg, ZEPBOUND 10 mg, ZEPBOUND 15 mg, or placebo, with an escalation period of up to 20 weeks followed by the maintenance period

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Clinical Trials in Cardiovascular Safety Tirzepatide shows positive effects on a variety of cardiovascular risk factors, but until now, the findings of just one study, SURPASS-4, have been used to report on the drug's cardiovascular safety [39]