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Renal function and blood pressure stability are also key eligibility criteria

The treatment effect reflected a reduction in a sustained decline in eGFR of 50%, progression to kidney failure and CV death

These approaches do not account for the fact that complex chronic diseases are driven by multiple distinct biological mechanisms, and that patients have different genetic and comorbidity backgrounds meaning they will respond differently to modulation of GLP-1 pathways

10.1007/s13679-022-00481-1