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In CVOTs, liraglutide, semaglutide and dulaglutide demonstrated appreciable cardiovascular and renal protective effects, among which liraglutide had an appreciable effect on mitigating the risk of cardiovascular death [4], while semaglutide and dulaglutide conferred a risk reduction on non-fatal stroke [22, 23]

Tirzepatide lowers blood sugar by stimulating insulin secretion and improving insulin sensitivity
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The cardiovascular outcomes suggest that GLP-1 therapy offers systemic health benefits beyond simple calorie restriction, making these medications attractive for overall metabolic health even in the absence of diabetes
SMR analyses As presented in Table 2 and Additional file 1: Fig
