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The starting dose affected side effects but not final outcomes

A 52 week study comparing the efficacy and safety of once weekly IcoSema and daily insulin glargine 100 units/mL combined with insulin aspart, both treatment arms with or without oral anti diabetic drugs, in participants with type 2 diabetes inadequately controlled with daily basal insulin (COMBINE 3)

Substantial weight lossa primary effect of these medicationstypically leads to decreased blood pressure, which is generally beneficial for patients with hypertension

By focusing on a treatment-nave population, this study aimed to provide a comprehensive real-world assessment of the comparative efficacy and tolerability of these two GLP-1 receptor agonists

It produced an average weight loss of 13.6% in trials, and gives people who would rather not inject an oral option
