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Several problems arise due to the unregulated nature of drug compounding, where the FDA does not oversee its production and the patients have no way of knowing about the exact contents of the drug

According to FDA prescribing information, nausea occurs in approximately 15-44% of patients depending on the specific agent and dose, with vomiting, diarrhea, constipation, and abdominal pain also frequently reported

Tirzepatide has an elimination half-life of approximately 5 days (approximately 120 hours), which is a critical pharmacokinetic parameter that enables once-weekly dosing