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This research theorized that hyperglycemia can lead to a downregulation of GIPr causing decreased GIP response despite therapeutic or even supratherapeutic levels of GIP [21]

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However, individual patient factors, including pre-existing cardiovascular conditions, may influence the clinical relevance of these changes

Activation of GLP-1R on vagal neurons increases gastric pressure [90]

Administration of semaglutide by doses of 150 and 300 mcg/kg showed an osteoprotective effect by a decrease in PYD level by 39.1% and 59.4% compared to the osteoporotic group