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9,12-15 A systematic review and meta-analysis of randomised controlled trials evaluating weight reduction diets, with or without exercise, reported an 18% reduction in all-cause mortality over a median follow up of two years in adults with obesity

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Furthermore, the data source used in this study encapsulated multiple hospital and physician networks, pharmacies, and health insurance companies, thereby increasing the relevance of the findings to patients seen in routine clinical practice

The continuous supply of progenitor and new epithelial cells physically promotes the transit of the latter from the crypts up to the villus tip, where they populate the newly vacant area of previously shed apoptotic epithelial cells (Gehart and Clevers, 2019)
