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When Should You Stop or Switch GLP-1 Drugs Because of Muscle Loss

Ozempic gets mentioned in many headlines, but the distinction matters

GLP-1s anti-apoptotic effects GLP-1 RAs exhibit strong anti-apoptotic effects by activating the PI3K/Akt pathway, which promotes cell survival by inhibiting pro-apoptotic factors such as Bax and caspase-3, while upregulating anti-apoptotic proteins like Bcl-2 (104106)

Notably, the ELIXA (lixisenatide) and EXSCEL (exenatide once weekly) trials yielded neutral results for their primary MACE endpoints, underscoring that cardiovascular benefit is not a uniform class effect [64]
