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Understanding why that distinction holds, what the numbers actually look like, and what you can do about it is the difference between treating muscle loss as an unavoidable cost and treating it as something you can shift

That doesn't happen because plan sponsors are generous (though many might be)

We do not accept "as low as" marketing claims unless the required payment can be independently verified

7.1 Synthesizing the discrepancy: a prevention-dominant model A conceptual representation of the proposed therapeutic window within this prevention-focused framework is shown in Figure 3

When adverse effects occur within the same exposure range required for efficacy and cannot be mitigated through dosing, formulation, or pathway bias, biological failure is likely