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Methodology: Fahad S

The medication suppresses appetite through direct receptor activation, and when that activation stops, appetite returns, often stronger than baseline due to metabolic adaptation

In a review of clinical trials, the combination of combined oral contraceptive pills (COCPs) with either a GLP-1RA or tirzepatide (GLP-1 and Glucose-dependent insulinotropic polypeptide (GIP) receptors agonist) did not affect the efficacy of contraceptive drugs, even though GLP-1RAs can decrease the absorption of the concomitantly administered drug through their gastric delaying effect

Excess body weight significantly increases pressure on weight-bearing joints, especially the knees and hips

doi: 10.1186/s12933-022-01604-7 130 KaragiannisTAvgerinosILiakosADel PratoSMatthewsDRTsapasAet al