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placebo when combined with a moderate-intensity lifestyle intervention (Supplementary Table 1)

GLP-1s are excellent at controlling appetite and the urge to eat, while berberine is effective at fixing the internal machinery of metabolism at a cellular level

#2: How do these medications work

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The function of GLP-1-RAs in treatment algorithms is expected to change and expand as more long-term evidence is collected and new medications are launched [96,97]