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The Midpoint Cohort (N=45) is a randomized, double-blind, sham-controlled study in adults who achieved at least 15% total body weight loss on tirzepatide

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Furthermore, from 2010-2023 the FDA has received 265 reports of suicidal thoughts in patients taking GLP-1 receptor agonists, particularly tirzepatide, liraglutide, and semaglutide, prompting a review of these medications [34,35]
Dehydration can affect kidney function, so keeping an eye on creatinine and eGFR levels is a good idea, especially if you have nausea or vomiting
