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Physicians, therefore, need to be fully aware of the advantages and disadvantages of the multiple and increasing treatment options available to them at each stage of the disease

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Introduction Glucagon-like peptide 1 receptor agonists (GLP-1 RAs) are key therapies for type 2 diabetes and obesity, regulating blood glucose by mimicking endogenous GLP-1

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Importantly, we demonstrated previously that exendin 939, generally considered a GLP-1R antagonist, enhances compound 2 efficacy (or vice versa) at the GLP-1R