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I think we will hear more about muscle loss over time - while less than fat loss, it is certainly an issue with GLP-1 RAs, and I suspect will become more of an issue in those not exercising sufficiently (so probably less of an issue in the body building community!)

Neuropsychologia, 36, 323-332

So, yes reduction of body fat mass while maintaining or building lean body mass is possible, which involves resistance training, an individualized healthy rate of fat loss, macronutrient / calorie modulation, high protein, supplements / nutraceuticals, plenty of low carb vegetables, etc

When to stop semaglutide before surgery is a critical question for patients taking this GLP-1 receptor agonist for diabetes or weight management

District Judge Karen Marston in Pennsylvania