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doi:10.1016/j.yjmcc.2014.03.007 7

For PCOS acne specifically that deep, cystic pattern along the jawline, chin, and neck that flares the week before your period spiro works because that exact distribution is androgen-driven
29 PRMT5 can similarly induce EMT and LNM via the modulation of Wnt4/-catenin pathway signaling

Increased sensitivity of the scalp and paresthesias have been reported rarely
