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These cytokines are sufficient and necessary for inducing both astrocyte transformation into neurotoxic A1 and blood-retina barrier destruction, resulting in the subsequent retinal ganglia cell death and various ophthalmopathy (Figure 4

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Sharif S, Van der Graaf Y, Cramer MJ, Kapelle LJ, de Borst GJ, Visseren FLJ, Westerink J, group Ss

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Surrogating and redirection of pyrazolo [1, 5-a] pyrimidin-7 (4H)-one core, a novel class of potent and selective DPP-4 inhibitors