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Frequent interruptions may lead to a "yo-yo" pattern that undermines long-term success

, Batterham, R

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Key weight loss results at 48 weeks by group: Response rates at 48 weeks (12 mg dose): 100% achieved greater than or equal to 5% weight loss 93% achieved greater than or equal to 10% weight loss 83% achieved greater than or equal to 15% weight loss The cardiometabolic improvements were also significant, with reductions in blood pressure, triglycerides, LDL cholesterol, HbA1c, fasting glucose, and fasting insulin across all dose groups

A 2024 study (SWIFT) tested a rapid initiation protocol: one day of buprenorphine, a 24-hour opioid-free period, then gradual titration of low-dose oral naltrexone before the injection