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Notably, a dose-dependent increase in heart rate, peaking at 24 weeks, subsequently decreased [19]

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However, GLP-1R agonists elicit nausea and vomiting 6,10 , and increase mean heart rate via directly stimulating sinoatrial node and enhancing sympathetic nervous system tone 10,11,12

We demonstrate that mGIPR-Ab/GLP-1 peptideantibody conjugates act on CNS GIP and GLP-1 receptors via CVOs to activate neural pathways, enabling the reduction of food intake and weight loss in obese mice

Double-Check Storage Guidelines: Some peptides remain stable at room temperature for several days