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However, PKA-activity appears to be essential for optimal incretin effects on stimulating insulin vesicle exocytosis." 5 There have been studies performed in animal subjects that show evidence of the pleiotropic effects of GLP-1 on beta cells such as beta cell regeneration and proliferation

(SURMOUNT-1 trial) Garvey WT et al

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It can also help improve overall health by reducing the risk of cardiovascular disease, improving blood sugar control, and increasing energy Trusted Source Effects of semaglutide on cardiovascular risk factors and eating behaviors in type 2 diabetes Di Folco U, Vallecorsa N, Nardone MR, Pantano AL, Tubili C Go to Source levels