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Trulicity activates the GLP-1 receptor, helping your body lower blood glucose by increasing insulin release when blood sugar is high, reducing how much glucose the liver produces, slowing stomach emptying, and helping you feel fuller sooner

Faure M, Guibert E, Alves S, et al

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We therefore suggest monitoring drug levels at least at the start of cotreatment with GLP1RAs, especially in patients with kidney dysfunction who are at risk for drug accumulation to toxic levels