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For humans, the model-predicted median clearance (CL) and volume of distribution (Vss) of semaglutide were 0.0397 L/h and 6.23 L, respectively

adults are obese, the CDC says

Researchers conducted a prospective single-center cohort study of adults with a BMI of 27 kg/m2 or higher using liraglutide (Victoza/Saxenda, Novo Nordisk) or semaglutide (Ozempic/Wegovy, Novo Nordisk)
