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Clinical trial data shows that most patients who experience early nausea go on to achieve significant weight loss once they adjust
showed no significant effect of leptin treatment (0.05 mg/kg/d metreleptin via subcutaneous injection) on body weight in women with overweight/obesity (53), and similar results were reported in men with overweight/obesity in a study performed by Hukshorn et al

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Semaglutide, marketed by the company Novo Nordisk, is also a GLP-1 agonist
