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Sanchez-Garrido MA, Brandt SJ, Clemmensen C, Muller TD, DiMarchi RD, Tschop MH
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If someone has taken Metformin at maximum tolerated dose for 6+ months with A1C still above 7.5%, adding Retatrutide offers substantial improvement potential
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Neither mechanism directly stimulates insulin secretion in a glucose-independent manner, making the combination inherently safer regarding hypoglycaemia compared to sulphonylureas or insulin
