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Indeed, the common hepatic branch, as well as celiac and gastric branches, have all been implicated in contributing to the glucoregulatory effects of gut GLP-1 62,125,126 , although selective knockdown of GLP-1R in nodose ganglia does not impair oral glucose tolerance or glucose-stimulated insulin secretion, similar to genetic knockout of GLP-1R in vagal neurons 127,128

GLP-1 GLP-1

This does not mean you need to change your tirzepatide timing, but you may need to adjust the timing of other medications relative to your injection

The lack of side effects is reassuring, making it something I feel comfortable recommending to friends

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