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11 Modulation of invariant natural killer T (iNKT) cells by GLP-1RAs was another mechanism demonstrated to improve psoriasis

These preclinical findings support clinical trial results showing that tirzepatide, a dual GIPR/GLP-1R agonist, exhibits greater anti-obesity effects than GLP-1 receptor agonists alone

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Tirzepatide Dosing Schedule Tirzepatide follows a similar gradual approach: Weeks 1-4: 2.5 mg weekly Weeks 5-8: 5 mg weekly Weeks 9-12: 7.5 mg weekly Weeks 13-16: 10 mg weekly Weeks 17-20: 12.5 mg weekly Weeks 21-24: 15 mg weekly (maximum dose) Why Gradual Dose Increases Matter Starting low and increasing slowly serves important purposes: Minimizes Side Effects: Your digestive system adapts gradually, reducing nausea and GI discomfort Identifies Your Optimal Dose: Some patients achieve excellent results at lower doses, avoiding unnecessary medication Sustainable Approach: Gradual weight loss (1-2 pounds weekly) is more likely to be maintained long-term though individual weight loss rates vary Safety First: Your body adjusts to the metabolic changes at a manageable pace Managing Your Treatment Experience Common Side Effects: What's Normal Most patients experience some side effects, particularly when starting treatment or increasing doses