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doi:10.1016/S2468-1253(23)00068-7 Knudsen LB, Lau J

Some patients find extended-release metformin easier to tolerate due to less severe gastrointestinal side effects

Without medical supervision, these symptoms may go unmanaged or be misinterpreted

doi: 10.1016/S0140-6736(14)61393-3 91 KimWSKgedalKHallidayGM

Call your clinician promptly if you have: Persistent vomiting, inability to keep fluids down, or signs of dehydration Severe or persistent abdominal pain (ask about pancreatitis and gallbladder warnings) Plans for surgery or procedures requiring anesthesia (labels include anesthesia-related precautions) Medication interactions: Zepbounds label notes it delays gastric emptying and may affect absorption of oral medications