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Maintaining a balanced diet, engaging in regular physical activity, and monitoring caloric intake are essential components for sustaining weight loss achieved through GLP-1 agonist therapy

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Both compounds cause primarily gastrointestinal side effects that peak during dose escalation

Compared to the use of GLP1-RAs alone, the combination of SGLT2is and GLP1-RAs was associated with a 30% reduction in the risk of MACE, with rates of 7.0 versus 10.3 events per 1000 person-years (HR 0.70

The net effect in clinical trials was a significant improvement in glycemic parameters, including reductions in HbA1c, fasting glucose, and insulin levels