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Retatrutide demonstrated 24.2% body weight reduction in Phase 2 trials, approaching bariatric surgery outcomes

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For employer plans, a single member using GLP-1 therapy can add thousands of dollars per year to claims costs

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SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors) such as empagliflozin, dapagliflozin, and canagliflozin represent excellent alternatives, providing cardiovascular and renal protection alongside modest weight loss (typically 2-4 kg)

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Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes

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doi: 10.1016/j.pnpbp.2010.07.004 36

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