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Why Weight Loss Stalls Weight loss may slow down while taking a GLP-1 medication for reasons similar to why plateaus occur when pursuing non-medication strategies to lose weight

Phase 2 Obesity Trial One of the most widely cited studies on retatrutide was a randomized Phase 2 clinical trial published in the New England Journal of Medicine in 2023

However, some patients may experience increased thirst due to related factors such as hyperglycaemia, dehydration from gastrointestinal side effects, or inadequate fluid intake

Further studies are required to elucidate the specific functions of GLP-1R across these diverse brain regions
