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Now, on top of that, we have zero data on this new chemical impurity's: Toxicity Short- or long-term effects Interaction with GLP-1 receptors Potential for immune reactions This finding reinforces the serious concerns already stated in the joint statement by the Obesity Medicine Association, The Obesity Society, and Obesity Action Coalition regarding compounded GLP-1 receptor agonists and their risks: Inconsistent dosing Potential contamination Lack of standard testing for clinical efficacy And now untested impurities formed by chemical interaction

Emerging effects of DPP-4 on bone metabolism include an inverse relationship between DPP-4 activity levels and bone mineral density, along with an increased risk of fractures