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F., Hou, Y., Lautrup, S., Jensen, M

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Dysregulation of specific transporters, such as the mitochondrial pyruvate carrier (MPC), citrate carrier (SLC25A1), and VDAC, critically disrupts metabolic fluxes, energy dynamics, and redox balance, underpinning diverse pathologies: exacerbating oxidative stress in NDDs, causing energy deficits in CVDs, driving insulin resistance in T2D, and supporting tumor survival via metabolic reprogramming (MR) in cancer

According to the degree of severity, stroke-related disability led to premature death with disability-adjusted life-years (DALYs) (47)

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