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[DOI] [PubMed] [Google Scholar] 93.Cho YM, Fujita Y, Kieffer TJ

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This means retatrutide activates the GIP receptor most aggressively, the GLP-1 receptor at moderate strength, and the glucagon receptor at the lowest level

Rapid weight loss without proper nutrition can lead to fatigue, muscle loss, nutrient deficiencies, digestive issues, and weight regain once medication use changes