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FDA approval applies to specific finished products manufactured under controlled conditions, not to the ingredient in general

Confirmed non-responder: Less than 5% body-weight loss after 24 weeks or longer, How Common Are GLP-1 Non-Responders

10.1016/j.neuro.2022.08.007 [DOI] [PubMed] [Google Scholar] 81.Jolivalt CG, Fineman M, Deacon CF, Carr RD, Calcutt NA (2011) GLP-1 signals via ERK in peripheral nerve and prevents nerve dysfunction in diabetic mice

But, a lot has changed since last summer and the numbers are something else

Endnotes These drugs are commonly prescribed for weight management, to treat type 2 diabetes, or to reduce the risk of heart attacks and stroke in people with cardiovascular disease