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doi: 10.2337/dc18-2028 [DOI] [PMC free article] [PubMed] [Google Scholar] 56

Long-term dosing with liraglutide causes C-cell hyperplasia, calcitonin production in a dose dependent manner, and tumor formation in rodents [121-123]

The majority of circulating biologically active GLP-1 in man is the GLP-1 (7-36) amide form, with lesser amounts of the bioactive GLP-1 (7-37) form also detectable (Orskov et al., 1994)

However, even if a particular bacterial genus and species has been correlated with a specific disease phenotype in a relatively reproducible manner in epidemiological studies [159] and proven to be causally involved in an intervention trial, differences between species, and even between strains, may also lead to different outcomes

This effect is usually mild and not dangerous for most people