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For evidence-based weight loss, prescription GLP-1 medications and structured lifestyle support remain the most reliable routes

doi: 10.1016/j.brainres.2013.01.012

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Currently, multiple phase 3 trials with oral semaglutide and orforglipron are ongoing for different populations (NCT05803421), while another oral GLP-1 RA (CT-996) is in early phase clinical trials (Table 1)