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In the periphery, GLP-1 acts directly on pancreatic islets to enhance GSIS (Mojsov et al., 1987) and inhibit glucagon release (Komatsu et al., 1989)

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This is true at any dose

Your provider should discuss realistic expectations: GLP-1 may not cause significant weight loss in non-overweight patients, but benefitsimproved glucose control, cardiovascular protection, reduced inflammationremain clinically meaningful