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Glickman notes that this works for a while (a little over a year, on average), the fact is that seven other hormones play a role in hunger and weight regulation, and theyre hardwired to prevent starvation

These effects result from semaglutide's action on GLP-1 receptors throughout the digestive tract and typically improve after 4-8 weeks at a stable dose

Similarly, tirzepatide is more effective at supporting weight loss than semaglutide but seems to have a poorer safety profile

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