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[43] Synthesis [edit] The synthesis of tirzepatide was first disclosed in patents filed by Eli Lilly and Company in 2016
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21, 2025, from Leehey, D.J., Rahman, M.A., Borys, E., et al

In humans, L585 cleavage by CPA reduces the plasma half-life of albumin from 3 weeks to 3.5 days due to loss of FcRn binding affinity 60

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