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Likewise, the anti-dipeptidyl peptidase-IV GLP-1RA ROSE-010 was shown to effectively relieve the intestinal pain induced by irritable bowel syndrome (101)

In the largest clinical trial that tested Wegovy before its FDA approval, people taking the highest dose (2.4 milligrams) lost, on average, more than 12% of their body weight over 17 months

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However, it was not derived from patient focus groups nor was it initially designed to quantify pain, which has limited its application in some settings

If they persist or worsen, contacting your healthcare provider is important