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1.2 Current challenges in diabetes and obesity management Obesity and diabetes are becoming increasingly common worldwide, presenting serious challenges for public health that cannot be ignored

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Previous reviews were inconclusive

The studies in the SURPASS program were similarly designed in terms of tirzepatide dosages, beginning with an initial dose of 2.5 mg administered weekly, followed by increments of 2.5 mg every four weeks until the final randomized treatment doses of 5, 10, or 15 mg of tirzepatide were achieved