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Surg Endosc [Internet]

Am J Physiol Endocrinol Metab 2008

Studied for: Cellular energy regulation Metabolic stress response Communication between mitochondria and nucleus Tissue, Skin & Inflammation Signaling GHK-Cu (Copper Peptide) Widely studied in tissue signaling and cellular repair models

The analysis included eight randomized controlled trials with 2,372 participants (all with BMI 27 kg/m) and found that weight regain was proportional to the amount initially lost.48 On average, participants who had taken liraglutide regained 2.2 kg, while those who had taken semaglutide or tirzepatide regained 9.69 kg after stopping the medication.48 Similarly, a 2025 review in Biomolecules showed that patients treated with GLP-1 or dual GLP-1/GIP agonists experience substantial weight loss (ranging from about 6% to over 20%) but also significant weight regain upon drug discontinuation