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Sergey Terushkin, MD, FACS Key Takeaways For decades, the field of bariatric medicine had two distinct lanes: lifestyle changes (which rarely produce massive, sustained weight loss for the morbidly obese) and bariatric surgery (which is highly effective but invasive)

However: Sustained caloric reduction Rapid weight loss Reduced dietary diversity Pre-existing marginal status May increase vulnerability in certain individuals

Aardvark Therapeutics ARD-101 Aardvarks lead candidate, oral ARD-101 , is a potent pan-agonist of bitter taste receptors (TAS2R) that stimulates enteroendocrine cells in the digestive tract, triggering the release of gut-peptide hormones like GLP-1 and cholecystokinin (CCK), a satiety hormone that activates gut-brain signaling to regulate hunger

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