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Therefore, based on these observations, the present Research Topic is to highlight to discuss 1) the mechanisms how "leptin resistance" is formed in obesity and 2) the possible strategy for ameliorating "leptin resistance"

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Some research protocols add compounds like MOTS-c (for mitochondrial fat oxidation), L-Carnitine (for fatty acid transport), or BPC-157 (for gut health support during GI side effects)