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180 A study that used 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to mimic PD-like neural injury found that neuroinflammation is aggravated in the midbrain of type 2 diabetes mice, who are more susceptible to the neurotoxicity induced by MPTP

This broadened inclusion criteria allowed for a more comprehensive understanding of drug effects in high-risk groups and supported the expansion of GLP-1R agonist indications beyond glycemic control to include cardiovascular and renal benefits
Studies have shown that patients using semaglutide (Ozempic) or tirzepatide (Mounjaro) can lose up to 15-20% of their body weight with proper medical supervision and lifestyle changes

Soluble CD26: From Suggested Biomarker for Cancer Diagnosis to Plausible Marker for Dynamic Monitoring of Immunotherapy

While further research is needed to confirm these effects, the current literature supports the potential utility of GLP-1RAs in IIH management
