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Here, the authors show that in mice berberine has beneficial glycemic effects by promoting insulin secretion, which requires the potassium channel KCNH6 in beta cells, and that berberine can promote insulin secretion in healthy men in a phase 1 clinical trial.

Polycythaemia vera is a member of the myeloproliferative neoplasms family of disorders and is characterized by an abnormal increase in red blood cell mass that is driven by activating mutations in JAK2